CLASStime: Medication wastage

In print

CLASStime: Medication wastage

By Sue Frankland
FRAZ Drug wastage
[Image: Fraser Williamson]

In this article, Sue Frankland looks at the global problem of wastage of medications, including causes such as overprescribing and non-adherence. She also presents information from her master’s dissertation on how people understand, and respond to, medication expiration dates

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1. Azad AK, Muhammad KR, Hossin MM, et al. Medication wastage and its impact on environment: Evidence from Malaysia. Pharmacologyonline 2016;3:114–21.

2. Peake BM, Braund R, Tong AYC, et al (Eds). The Life-Cycle of Pharmaceuticals in the Environment. Woodhead Publishing; 2016.

3. Whyte SR, van der Geest S, Hardon A (Eds). Social Lives of Medicines. Cambridge University Press; 2002.

4. van der Geest S, Whyte SR, Hardon A. The anthropology of pharmaceuticals: A biographical approach. Annual Review of Anthropology 1996;25:153–78.

5. Moynihan R, Heath I, Henry D. Selling sickness: the pharmaceutical industry and disease mongering. BMJ 2002;324(7342):886–91.

6. Kasamo S, Matsumoto S, Kawasaki Y, et al. Changes in prescribing trends and initial pharmacotherapy of children with nocturnal enuresis in Japan: a large-scale medical claims database analysis. World J Urol 2021;39(9):3517–24.

7. Darling JC. Management of nocturnal enuresis. Trends in Urology, Gynaecology & Sexual Health 2010;15(3):18–22.

8. D’Souza S, Bowden N, Gibb S, et al. Medication dispensing for attention-deficit/hyperactivity disorder to New Zealand youth. N Z Med J 2020;133(1522):84–95.

9. Bowden N, Gibb S, Thabrew H, et al. IDI trends in antidepressant dispensing to New Zealand children and young people between 2007/08 and 2015/16. N Z Med J 2019;132(1505):48–61.

10. Burghardt LC, Ayers JW, Brownstein JS, et al. Adult prescription drug use and pediatric medication exposures and poisonings. Pediatrics 2013;132(1):18–27.

11. Brown MT, Bussell JK. Medication adherence: WHO cares? Mayo Clin Proc 2011;86(4):304–14.

12. Horne R, Chapman SC, Parham R, et al. Understanding patients’ adherence-related beliefs about medicines prescribed for long-term conditions: a meta-analytic review of the Necessity-Concerns Framework. PLoS One 2013;8(12):e80633.

13. Lehane E, McCarthy G. Intentional and unintentional medication non-adherence: a comprehensive framework for clinical research and practice? A discussion paper. Int J Nurs Stud 2007;44(8):1468–77.

14. Mitchell AJ, Selmes T. Why don’t patients take their medicine? Reasons and solutions in psychiatry. Advances in Psychiatric Treatment 2007;13(5):336–46.

15. Liu F, Ranmal S, Batchelor HK, et al. Patient-centred pharmaceutical design to improve acceptability of medicines: similarities and differences in paediatric and geriatric populations. Drugs 2014;74(16):1871–89.

16. Allemann SS, Nieuwlaat R, Navarro T, et al. Congruence between patient characteristics and interventions may partly explain medication adherence intervention effectiveness: an analysis of 190 randomized controlled trials from a Cochrane systematic review. J Clin Epidemiol 2017;91:70–79.

17. Hodgetts D, Nikora LW, Rua M. Māori men and the indirect procurement and sharing of prescription medications. AlterNative: An International Journal of Indigenous Peoples 2011;7(2):152–62.

18. Okuboyejo S. Non-adherence to medication in outpatient setting in Nigeria: the effect of employment status. Glob J Health Sci 2014;6(3):37–44.

19. Hughes CM. Medication non-adherence in the elderly: how big is the problem? Drugs Aging 2004;21(12):793–811.

20. Gold DT, McClung B. Approaches to patient education: emphasizing the long-term value of compliance and persistence. Am J Med 2006;119(4 Suppl 1):S32–37.

21. Elliott R. Non-adherence to medicines: not solved but solvable. J Health Serv Res Policy 2009;14(1):58–61.

22. Yeoman G, Furlong P, Seres M, et al. Defining patient centricity with patients for patients and caregivers: a collaborative endeavour. BMJ Innov 2017;3(2):76–83.

23. du Plessis D, Sake JK, Halling K, et al. Patient centricity and pharmaceutical companies: Is it feasible? Ther Innov Regul Sci 2017;51(4):460–67.

24. Phillion M. Improving Medication Adherence Through Patient Centricity. Patient Safety and Quality Healthcare, 8 October 2021.

25. Desai RJ, Sarpatwari A, Dejene S, et al. Comparative effectiveness of generic and brand-name medication use: A database study of US health insurance claims. PLoS Med 2019;16(3):e1002763.

26. Straka RJ, Keohane DJ, Liu LZ. Potential clinical and economic impact of switching branded medications to generics. Am J Ther 2017;24(3):e278–89.

27. Al-Arifi MN. Assessment of knowledge, attitudes, and factors influencing the selection student of generic medicine. Front Public Health 2021;9:767128.

28. Dunne SS, Dunne CP. What do people really think of generic medicines? A systematic review and critical appraisal of literature on stakeholder perceptions of generic drugs. BMC Med 2015;13:173.

29. Virdi VJS, Gupta M, Gupta R. Hurdles in mandatory generic medicine prescription. Journal of Pharmacology and Pharmacotherapeutics 2021;12(3):115–19.

30. Cohen LP. Many Medicines Are Potent Years Past Expiration Dates. The Wall Street Journal, 28 March 2000.

31. Wilson NLW, Rickard BJ, Saputo R, et al. Food waste: The role of date labels, package size, and product category. Food Quality and Preference 2017;55:35–44.

32. De Winter S, Vanbrabant P, Vi NT, et al. Impact of temperature exposure on stability of drugs in a real-world out-of-hospital setting. Ann Emerg Med 2013;62(4):380–87.e1.

33. Willner S, Whittemore R, Keene D. “Life or death”: Experiences of insulin insecurity among adults with type 1 diabetes in the United States. SSM Popul Health 2020;11:100624.

34. Cialdini RB, Wosinska W, Barrett DW, et al. Compliance with a request in two cultures: The differential influence of social proof and commitment/consistency on collectivists and individualists. Personality and Social Psychology Bulletin 1999;25(10):1242–53.

35. Miron AM, Brehm JW. Reactance Theory – 40 years later. Zeitschrift Fur Sozialpsychologie 2006;37:9–18.

36. Lin CP, Tsai MC, Sun CY, et al. Stability of self-prepared fortified antibiotic eyedrops. Kaohsiung J Med Sci 1999;15(2):80–86.

Figure: Van Alsten SC, Harris JK. Cost-related nonadherence and mortality in patients with chronic disease: A multiyear investigation, National Health Interview Survey, 2000–2014. Prev Chronic Dis 2020;17:E151.